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KMID : 0613820020120010106
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Journal of Life Science
2002 Volume.12 No. 1 p.106 ~ p.112
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Plasma Cholesterol-Lowering Effects of Cinnamomi cortex Extract as an Inhibitor of Pancreatic Cholesterol Esterase
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Kim Hee-Sook
Choi Jong-Won
Hur Young-Mi
Ryu Sung-Ho
Suh Pan-Ghil
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Abstract
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Ethanol extract of Cinnamomi cortex inhibited potently cholesterol esterase activity in vitro. Chloroform fraction of ethanol extract showed the stronger inhibitory effect than other solvent fractions - ethylacetate fraction, butanol fraction, and aqueous fraction. The chloroform fraction of Cinnamomi cortex was studied as a candidator of plasma cholesterollowering material using high cholesterol-fed rats. In high cholesterol-fed rats, the diet with chloroform fraction of 150 mg/kg lowered not only plasma neutral lipids contents 25.1% but also plasma total cholesterol level 49.6% than only high cholesterol diet. Plasma HDL-cholesterol level in Cinnamomi cortex chloroform fraction-fed rats was recovered as
those level of normal rats. LD50 of Cinnamomi chloroform extract was calculated as 1,300 mg/kg.
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KEYWORD
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Cinnamomi cortex, pancreatic cholesterol esterase, pCEase, acyl CoA: cholesterol acyltransferase, Atherogenic Index
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